Causes of Neck Lumps

Neck lumps have many causes but, thankfully, the majority are benign. However, a number of benign lumps will still need to be assessed, partly to rule out the possibility of anything more sinister being behind them but also in case surveillance or surgery is required.

To simplify the different possible diagnosis I tend to divide neck lumps into the following common categories:

Lumps arising from lymph nodes in the neck

Thankfully the majority of lumps arising from lymph nodes are benign. Lymph nodes are part of the immune system. They are often described as being reactive as they enlarge in response to infections or inflammation in the head and neck region. The most common reason for a lump in the neck arising from a lymph node is an upper respiratory tract infection (including pharyngitis and tonsillitis) but they can also occur as a result of inflammation from scalp dermatitis or psoriasis.

Unfortunately, malignant lymph node lumps do also occur and this must be considered if a lump arising from a lymph node is getting progressively bigger or is associated with other upper respiratory or digestive tract symptoms such as ear pain, hoarseness and difficulty or pain on swallowing. Risk factors for head and neck cancers such as smoking and alcohol intake must also be enquired about as these raise the level of suspicion. These lymph nodes urgently require a sample of cells to be analysed so that an almost immediate diagnosis can be made.

Malignancy of the lymph nodes in the form of lymphoma also occurs and should be thought of for anyone with a progressively enlarging lymph node. These patients often require a needle biopsy of the lymph node or a formal removal for diagnosis and then a referral on to a specialist haematology-oncology team.

Lumps present from birth (congenital)

The two most common congenital lumps include a thyroglossal duct cyst and a branchial cyst.

Thyroglossal duct cyst

A thyroglossal cyst forms in the remnant of the duct that is formed whilst babies are developing in the womb as the thyroid gland moves from the back of the tongue to the lower part of the neck. These cysts typically form a neck lump that is just off centre, often around the hyoid bone level. The hyoid bone is horse-shoe shaped and it anchors the tongue. They can cause an acute infection and therefore they are red, painful and cause discomfort on swallowing. These can become a recurrent problem and often are visibly obvious. Surgical approaches to these must be thorough so as to remove all aspects of the cyst, the duct and the mid-portion of the hyoid bone in order to reduce recurrence.



Branchial cyst

These cysts are usually seen in the first two decades of life often in association with an upper respiratory tract infection. They may seem just like lymph node lumps but sometimes they can expand to a significant size. They are always sited high in the neck, tucked under the long muscle in the side of the neck that runs from the throat to behind the ear (the sternocleidomastoid muscle). These can be very troublesome and can cause repeated infections. However, the removal  can be extremely difficult as they lie on top of the internal jugular vein and carotid arteries, which carry blood to and from the brain and alongside a number of very important nerves in the neck.

Salivary Gland swellings

We have three pairs of major salivary glands (parotid, submandibular and sublingual) and many minor salivary glands. Lumps in the neck caused by salivary glands will usually be parotid and submandibular salivary gland swellings. Both of these may be affected by inflammatory conditions.

Parotid gland lumps

The majority (90%) of lumps in the parotid gland are benign and of these the majority (80-90%) are a common benign tumour called a ‘pleomorphic adenoma’. These do require to be assessed as they still have a small malignant potential and will probably grow. As they are easier to remove when they are smaller it is sensible to discuss the pros and cons of a surgical approach to them as early as possible. Surgery is often in the form of a parotidectomy, where the facial nerve that supplies the muscles of the face is located and preserved whilst the tumour and part of the parotid is removed. This should be done by a surgeon who regularly performs this procedure as damage to the facial nerve can leave patients with a weakness that is visually obvious for the rest of their lives.

Malignant parotid tumours are thankfully rare but their symptoms are rapidly enlarging parotid swellings, pain and even facial nerve weakness.

Submandibular gland lumps

When a swelling occurs in the submandibular region the likelihood of this being malignant increases compared with a parotid swelling. Imaging and fine needle aspiration cytology will be performed, as with a parotid swelling, and then appropriate plans will be made for the swelling to be surgically removed.

Thyroid swellings

A swelling of the thyroid gland is often referred to as goitre. The majority of swellings and lumps in the thyroid gland are completely benign. Thyroid cancer itself is extremely rare. A lump in the thyroid does however require investigation so that a diagnosis of a benign swelling can be made. Ultrasound and fine needle aspiration are used after a full clinical history and examination have been undertaken. Often a repeat fine needle aspiration will be undertaken a few months after the first to completely confirm that the thyroid lump is benign.

Surgical removal of the thyroid gland may be undertaken for the following reasons:

  • Malignant disease of the thyroid
  • Suspicion of malignant disease of the thyroid
  • Compression of the airway (oesophagus) by the thyroid gland
  • Uncontrolled medical problems of the thyroid
  • Cosmetic reasons


There are many different causes of head and neck lumps. Fortunately, the majority of neck lumps are benign, however in order to reach a correct diagnosis it is essential for patients to be evaluated by an appropriate specialist team of doctors. Having been evaluated by the appropriate team the patient will either be reassured and offered appropriate advice on any further steps that may be required or, alternatively, they will commence their journey down a cancer pathway that can be steered by the team in the neck lump clinic. Rapid processing and early detection and treatment will help with the overall outcome for all patients with neck lumps.

See also - Neck Lump FAQs


A Visual Guide to Lumps and Bumps


Rapid Access Neck Lump Clinic

For further information on the author of this article, Consultant ENT / Head and Neck Surgeon, Mr Francis Vaz, please click here.
Has a sudden onset. Full medical glossary
A benign tumour that forms from glandular cells. Full medical glossary
The withdrawal of fluid or cells from the body by suction. Full medical glossary
Not dangerous, usually applied to a tumour that is not malignant. Full medical glossary
An abnormal swelling that is not cancerous; in other words, it does not invade local tissues or spread to distant parts of the body. Full medical glossary
The removal of a small sample of cells or tissue so that it may be examined under a microscope. The term may also refer to the tissue sample itself. Full medical glossary
A fluid that transports oxygen and other substances through the body, made up of blood cells suspended in a liquid. Full medical glossary
A minor birth defect resulting from a developmental disorder of the neck and collarbone during embryonic development Full medical glossary
Abnormal, uncontrolled cell division resulting in a malignant tumour that may invade surrounding tissues or spread to distant parts of the body. Full medical glossary
The two main arteries in the neck. Full medical glossary
The basic unit of all living organisms. Full medical glossary
Any condition present since birth. Full medical glossary
A fluid-filled, enclosed pouch developing in a bodily structure as part of a disease process Full medical glossary
The study of individual cells. Full medical glossary
The process of determining which condition a patient may have. Full medical glossary
The abbreviation for ear, nose and throat. Full medical glossary
The withdrawal of fluid or cells from a bodily structure, such as a cyst, through a syringe, to enable further analysis Full medical glossary
An organ with the ability to make and secrete certain fluids. Full medical glossary
Swelling of the thyroid gland due to inflammation, producing a lump in the neck Full medical glossary
The organs specialised to fight infection. Full medical glossary
Invasion by organisms that may be harmful, for example bacteria or parasites. Full medical glossary
The body’s response to injury. Full medical glossary
A watery or milky bodily fluid containing lymphocytes, proteins and fats. Lymph accumulates outside the blood vessels in the intercellular spaces of the body tiisues and is collected by the vessels of the lymphatic system. Full medical glossary
Small, rounded organs of the immune system that are distributed along the lymphatic system that filter lymph, a fluid derived from the blood, and produce antibodies and a type of white blood cells, lymphocytes. Full medical glossary
A type of cancer that affects the lymph nodes, part of the immune system. Full medical glossary
Describes a tumour resulting from uncontrolled cell division that can invade other tissues and may spread to distant parts of the body. Full medical glossary
Tissue made up of cells that can contract to bring about movement. Full medical glossary
Bundle of fibres that carries information in the form of electrical impulses. Full medical glossary
Bundles of fibres that carry information in the form of electrical impulses. Full medical glossary
The gullet, the part of the gastrointestinal system that extends down from the mouth cavity to the stomach. Full medical glossary
Removal of part or all of the parotid gland, a salivary gland that lies in front of and below the ear. Full medical glossary
Inflammation of the pharynx - the medical term for a sore throat Full medical glossary
A craving to eat non-food substances such as earth or coal. Full medical glossary
Continuously increasing in extent or severity. Full medical glossary
A chronic skin disease causing red, scaly patches that may be intensely itchy. It is sometimes associated with arthritis (psoriatic arthritis). Full medical glossary
The parts of the body that are involved in respiration. The respiratory tract includes the nasal passages, throat (pharynx), windpipe (trachea), bronchi and lungs. Full medical glossary
A cyst that forms from a persistent duct that normally disappears during the development of the embryo. It causes a swelling in the neck Full medical glossary
A gland in the neck that produces hormones with a role in controlling metabolism. Full medical glossary
Inflammation of the tonsils, lymphatic tissues at the back of the throat Full medical glossary
An abnormal swelling. Full medical glossary
A blood vessel that carries blood towards the heart. Full medical glossary
Relating to the sense of sight (vision). Full medical glossary
The uterus. Full medical glossary