Top 10 reasons to be happy about hormone replacement therapy
London PMS & Menopause Clinic
- HRT will stop your hot flushes and sweats
- Oestrogens will treat vaginal dryness and many causes of painful intercourse and lack of libido
- HRT increases the bone density and prevents osteoporotic fractures
- HRT protects the intervertebral discs
- HRT does reduce the number of heart attacks
- Oestrogens help depression in many women
- HRT improves libido
- HRT improves the texture of the skin
- "I am a nicer person to live with"
- HRT is safe
Troublesome hot flushes and severe night sweats that can cause chronicA disease of long duration generally involving slow changes. insomnia are characteristic symptoms of the menopauseThe time when a woman's periods permanently cease.. They may last for years and apart from being socially embarrassing they result in tiredness because of lack of sleep as well as depression. These symptoms can be cured with the correct dose of oestrogenA hormone involved in female sexual development, produced by the ovaries.. No other treatment is nearly as effective.
Thinning of the vaginal skin producing vaginal dryness is another characteristic sign of oestrogen deficiency that occurs after the menopause. This also can be successfully treated with oestrogen either by tablets, or through the skin by patches or gels or implants. Going through the skin is probably the safest and most effective route. Oestrogens can also be given for this symptom by local vaginal applications of a weak oestrogen that is not absorbed. Other related problems of painful intercourse, loss of libido are, depending upon the cause, also effectively treated by oestrogens.
Every study confirms that oestrogens are the most effective way of increasing bone density and this treatment is certainly very safe when started in women under the age of 60. It is much more effective and beneficial than the bisphosphonatesA family of drugs that prevent the break down of bone by cells called osteoclasts. frequently used by bone physicians and general practitioners. These non-hormonal drugs with their considerable long term complications have no place in maintaining bone density in women under the age of 60. For younger women receiving oestrogen therapy for flushes, sweats or vaginal dryness there will be a considerable increase in bone density over the years to such an extent that osteoporotic fractures 20 years later are much less likely to occur. For women who have low bone density, even without typical menopausalRelating to the menopause, the time of a woman’s life when her ovaries stop releasing an egg (ovum) on a monthly cycle. symptoms, oestrogens must be seen as first choice therapy.
The oestrogens prevent the collagen being lost from the intervertebral discs. These discs make up one quarter of the length of the spinal cord and act as cushions preventing crush fractures of the vertebral bones. It is these crush fractures that result in loss of height and of the bending forward of the upper spine known as a Dowager’s hump. This important protective effect of oestrogens seems to be unique as bisphosphonatesA class of drugs used in osteoporosis and other bone diseases to reduce loss of bone mass and the other non hormonal treatments of low bone density do not have any affect upon the discs.
There is about 30 years of evidence from many observational trials showing that oestrogens reduce the problems of coronaryRelating to the arteries supplying the heart itself. disease and heart attacks. This has subsequently been questioned by the 2002 Women’s Health Initiative (WHI) study which showed an increase in heart attacks. However, this study looked at the wrong aged patients, using the wrong dose and subsequent reports from the same investigators showed a very much reduced incidenceThe number of new episodes of a condition arising in a certain group of people over a specified period of time. of heart attacks in women who start HRT below the age of 60. This is particularly so in women who have had a hysterectomyThe surgical removal of the uterus (womb). and can have oestrogens without progestogen. The view now is that HRT particularly oestrogen alone is very safe and very beneficial if started below the age of 60.
There is no doubt that depression is helped in post menopausal women who have been suffering from night sweats, insomnia or vaginal dryness, painful intercourse and marital problems. However, the most impressive effect on mood is seen in younger perimenopausal women in the two or three years before the periods cease. This is known as the menopausal transition period. Such depression often occurs in women who previously have had post natal depression and premenstrual depression. As premenstrual depression becomes worse with age it blends with the more severe depression of the transition phase but is very effectively treated by oestrogens through the skin i.e. transdermal therapy.
HRT certainly improves libido if oestrogens are used to cure vaginal dryness and painful intercourse. However, if necessary, the addition of testosteroneThe main male sex hormone. has an even more dramatic effect upon libido, frequencyApplied to urination, needing to urinate more often than normal, for whatever reason. of intercourse and intensity of orgasm. Women must be aware that testosterone is not a male hormoneA substance produced by a gland in one part of the body and carried by the blood to the organs or tissues where it has an effect.. It is an essential female hormone that is present, in women, in 10 times the bloodA fluid that transports oxygen and other substances through the body, made up of blood cells suspended in a liquid. levels as is oestrogen. It is an essential hormone, important for energy, mood and sexuality in women and is particularly needed in women who have had a hysterectomy with loss of ovariesFemale reproductive organs situated one on either side of the uterus (womb). They produce egg cells (ova) and hormones in a monthly cycle. and ovarianrelating to the ovaries androgens
After the menopause, women lose about 25% of their body collagen which are manifested by thin inelastic skin, brittle nails, loss of hair and loss of the collagenous bone matrix. This latter loss is an essential cause of osteoporosisA condition resulting in brittle bones due to loss of bony tissue. and osteoporotic fractures. Oestrogen therapy replaces the lost collagen in the skin and the bone and nails. Its effect on the skin of the face is a very obvious useful cosmetic effect.
Many women say that when oestrogen therapy stops their depression, their loss of libido and their irritability, they become nicer people for their partners to live with. The depression, grumpiness and loss of energy can usually be improved considerably by the appropriate doses of the appropriate hormones. This may be testosterone as well as oestrogen.
In spite of the press reports stressing bad news, virtually all of the major side effects from the WHI study have been withdrawn even by the investigators. It seems quite clear that the major side effects occurred in women who started the wrong dose of HRT over the age of 60. In women who started below the age of 60 there were fewer heart attacks, fewer deaths, fewer osteoporotic fractures and even less breast cancerAbnormal, uncontrolled cell division resulting in a malignant tumour that may invade surrounding tissues or spread to distant parts of the body.. The one residual side effect is that there probably is a very slight i.e. 1% extra lifetime risk of developing breast cancer but this is no more than the breast cancer risk of being overweight, drinking wine, having no children or even taking statinsA class of drugs that inhibit cholesterol formation in the liver..
For further information on the author of this article, Consultant Gynaecologist, Professor John Studd, please click here.
For Osteoporisis Expert - see Professor David Reid