New heart drug for atrial fibrillation

Final guidance from the National Institute for Health and Clinical Excellence (NICE) has recommended the prescription of rivaroxaban for the prevention of stroke and embolism in patients with atrial fibrillation (AF). The drug works by preventing the blood from clotting which is important in the treatment of AF patients who are at a five times greater risk of developing blood clots and suffering a stroke.

Rivaroxaban, which stops the formation of thrombin and fibrin (key components in blood clotting) has been authorised for patients with non-valvular atrial fibrillation who also have hypertension or diabetes, are over the age of 75, or have had previous strokes or transient ischaemic attacks (TIAs). However, the medication is not without side effects and will only be offered to patients once they have had a full discussion with their doctor about the risks and benefits of the two heart drugs, rivaroxaban and warfarin.

The side effects of both anti-coagulant drugs include problems with bleeding; warfarin has been known to cause haemorrhages and rivaroxaban can cause nose bleeds, bleeding from the gums and blood in vomit or urine.

If you would like more information on the latest treatments for atrial fibrillation, a common heart rhythm disorder, see ‘Laser balloon ablation for atrial fibrillation’ by Dr Oliver Segal, Consultant Cardiologist at University College Hospital London.

An abbreviation for atrial fibrillation Full medical glossary
The two upper chambers of the heart. Full medical glossary
A common abnormal heart rhythm causing a rapid, irregular pulse and failure of the upper chambers of the heart (atria) to pump properly. Abbreviated to AF. Full medical glossary
A fluid that transports oxygen and other substances through the body, made up of blood cells suspended in a liquid. Full medical glossary
Relating to the heart Full medical glossary
The basic unit of all living organisms. Full medical glossary
Blood that has coagulated, that is, has moved from a liquid to a solid state. Full medical glossary
A disorder caused by insufficient or absent production of the hormone insulin by the pancreas, or because the tissues are resistant to the effects. Full medical glossary
Obstruction of blood flow by an embolus, a clot (or other material, for example, fat or air) that has become dislodged from elsewhere in the blood system. Full medical glossary
Abnormally fast and uneven contractions of the heart muscle, so that blood cannot be pumped efficiently Full medical glossary
A product of blood coagulation that forms the basis of a blood clot. Full medical glossary
The internal or external loss of blood from a blood vessel. Full medical glossary
High blood pressure. Full medical glossary
intermittent claudication Full medical glossary
A large abdominal organ that has many important roles including the production of bile and clotting factors, detoxification, and the metabolism of proteins, carbohydrates and fats. Full medical glossary
Any sudden neurological problem caused by a bleed or a clot in a blood vessel. Full medical glossary
An enzyme that converts fibrinogen to fibrin during blood coagulation. Full medical glossary
Transient ischaemic attack; a brief interruption of the blood supply to part of the brain, which causes temporary impairment of vision, speech, sensation or movement.. Full medical glossary
Any neurological problem caused by an interruption in the blood supply to the brain that resolves within 24 hours. Abbreviated to TIA. Full medical glossary
An anti-coagulant drug used to treat and prevent abnormal blood clotting. Full medical glossary