AI improves accuracy of blood tests for heart disease

A new generation of diagnostic testing that utilises machine learning or artificial intelligence (AI), combined with testing for the presence of diagnostic markers, and with specific algorithms is starting to deliver a new era of diagnostic accuracy for cardiovascular disease.

Significantly improving accuracy of heart diagnostics

According to recent reports following the 2021 American College of Cardiology Scientific Sessions, the new technology combinations significantly improve the accuracy of standard-of-care stress tests, coronary artery calcium scores, single blood tests such as troponin, genetic markers, clinical risk scores (such as Framingham risk) and multi-protein tests.

Resting ECGs do not normally provide sufficient information on the heart condition. Exercice ECG or treadmill tests (TMT) are notoriously inaccurate with high FP (false positive rates) and these can result in unnecessary referrals for invasive coronary angiography. According to the European Heart Journal, "Half of positive TMT were FP in a population of patients referred for ICA following clinical judgment and a TMT positive for ischemia". Individual blood tests in isolation also fall short in providing the full picture.

New generation of heart diagnostics

Simple, accurate, non-invasive tests are therefore going to be highly preferred. The ability to accurately detect and predict the presence of obstructive coronary artery disease (CAD) is primary aim in most clinical settings. The latest technologies include the (AI)-driven HART platform from Prevencio Inc.

Ahead of the standard curve

Machine learning (AI) is now spearheading most new medical initiatives and this is naturally impacting on pathology (clinical laboratory testing) too. Combining sources of data such as clinical informatics,  genomics, proteomics, bioinformatics, and biostatistics - into clinical practice is upgrading many approaches for patient care.

This development will be good news for patients admitted to A&E with adverse cardiac events or acute chest pain who require rapid and accurate diagnostic testing for myocardial infarction (heart attack). Also, in outpatients where a noninvasive test can identify obstructive coronary artery disease (CAD) where chest pain needs to be evaluated. The test might also improve diagnostic accuracy as well as management with triage throughput, and secondary prevention.

Has a sudden onset. Full medical glossary
X-ray imaging of the blood vessels following the injection of a dye to improve visibility. Full medical glossary
A blood vessel that carries blood away from the heart. Apart from the pulmonary artery and umbilical artery, all arteries carry oxygenated blood. Full medical glossary
A fluid that transports oxygen and other substances through the body, made up of blood cells suspended in a liquid. Full medical glossary
An element that forms the structure of bones and teeth and is essential to many of the body's functions. Full medical glossary
Relating to the heart Full medical glossary
Disease of the heart and blood vessels, usually due to atherosclerosis. Full medical glossary
Relating to the arteries supplying the heart itself. Full medical glossary
Narrowing of the blood vessels supplying the heart muscle, leading to symptoms such as angina and sometimes to a heart attack or myocardial infarction Full medical glossary
The abbreviation for electrocardiogram, a tracing of the electrical activity of the heart to help in the diagnosis of heart disease. Full medical glossary
The basic unit of genetic material carried on chromosomes. Full medical glossary
Relating to the genes, the basic units of genetic material. Full medical glossary
The death of a section of heart muscle caused by an interruption in its blood supply. Also called a myocardial infarction. Full medical glossary
intermittent claudication Full medical glossary
Death of a piece of tissue owing to obstruction of its blood supply. Full medical glossary
Death of a portion of tissue due to inadequate blood supply Full medical glossary
A large abdominal organ that has many important roles including the production of bile and clotting factors, detoxification, and the metabolism of proteins, carbohydrates and fats. Full medical glossary
Any test or technique that does not involve penetration of the skin. The term 'non-invasive' may also describe tumours that do not invade surrounding tissues. Full medical glossary
Compounds that form the structure of muscles and other tissues in the body, as well as comprising enzymes and hormones. Full medical glossary
Relating to injury or concern. Full medical glossary
A group of proteins found in muscle. Full medical glossary
Relating to blood vessels. Full medical glossary