Protein discovered that can indicate the severity of brain disease

Recent research has identified a protein in the blood that could be a good indicator of the severity of brain disease. The protein, called Clusterin, is thought to affect the size of the human brain causing it to shrink, which can rapidly increase the progression of Alzheimer’s disease. 

The study was carried out by the Erasmus MC University in Rotterdam and included 1000 people suffering from Alzheimer’s disease. Those individuals with the highest levels of Clusterin also had the most severe cases of Alzheimer’s disease. The findings, which are published in the Journal of the American Medical Association, also suggest that higher levels of Clusterin did not appear before the onset of Alzheimer’s meaning it might not be suitable as an early warning sign. 

Dr Marie Janson, from the charity Alzheimer’s Research UK, said: "A blood test to detect Alzheimer’s is a key goal of worldwide dementia research and these findings tell us more about the proteins a test may need to spot. An accurate, reliable test will help us develop new treatments by revealing who would benefit most and at what stage." 

A fluid that transports oxygen and other substances through the body, made up of blood cells suspended in a liquid. Full medical glossary
Decline in mental capacity, brain functioning and memory that affects day-to-day living. Full medical glossary
Compounds that form the structure of muscles and other tissues in the body, as well as comprising enzymes and hormones. Full medical glossary